| Name | Entered office | Left office | Party | Notes |
|---|---|---|---|---|
| Leo Amery | 11 June 1925 | 4 June 1929 | Conservative | |
| The Lord Passfield | 7 June 1929 | 5 June 1930 | Labour | |
| James Thomas | 5 June 1930 | 22 November 1935 | Labour/National Labour | |
| Malcolm MacDonald | 22 November 1935 | 16 May 1938 | National Labour | |
| Lord Stanley | 16 May 1938 | 31 October 1938 | Conservative | |
| Malcolm MacDonald | 31 October 1938 | 29 January 1939 | National Labour | |
| Sir Thomas Inskip | 29 January 1939 | 3 September 1939 | Conservative | |
| Anthony Eden | 3 September 1939 | 14 May 1940 | Conservative | |
| The Viscount Caldecote | 14 May 1940 | 3 October 1940 | Conservative | |
| Viscount Cranborne | 3 October 1940 | 19 February 1942 | Conservative | |
| Clement Attlee | 19 February 1942 | 24 September 1943 | Labour | |
| Viscount Cranborne | 24 September 1943 | 26 July 1945 | Conservative | |
| The Viscount Addison | 3 August 1945 | 7 July 1947 | Labour |
Succeeded by the Secretary of State for Commonwealth Relations